Genomic Medicine, Biomarkers, and Health Sciences
Volume 3, Issue 1 , Pages 17-26, March 2011

Application of Embryonic Stem Cells on Parkinson's Disease Therapy

  • Jenn-Rong Yang

      Affiliations

    • Division of Physiology, Livestock Research Institute, Council of Agriculture, Executive Yuan, Tainan, Taiwan
    • Institute of Biomedical Science, National Sun Yat-Sen University, Kaohsiung, Taiwan
    • ,
  • Yu-Ting Lin

      Affiliations

    • Division of Physiology, Livestock Research Institute, Council of Agriculture, Executive Yuan, Tainan, Taiwan
    • ,
  • Chia-Hsin Liao

      Affiliations

    • Department of Medical Research, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan
    • Institute of Medical Science, Buddhist Tzu-Chi University, Hualien, Taiwan
    • Corresponding Author InformationCorresponding author. Department of Medical Research, Buddhist Tzu-Chi General Hospital, Institute of Medical Science, Buddhist Tzu-Chi University, 9F, No. 707, Section 3, Chung-Yang Road, Hualien County 970, Taiwan

Received 29 December 2010; received in revised form 24 January 2011; accepted 26 January 2011.

Article Outline

Embryonic stem (ES) cells have the ability to reproduce themselves for a long period and differentiate into specific morphological and functional cells. The ES cells are an important material in developmental biology, genomics, and transgenic methods, as well as in potential clinical applications, gene therapy and tissue engineering. The pluripotent ES cells will be a valuable source in the treatment of numerous functional degenerative pathologies including Parkinson's disease (PD), which is characterized by progressive and selective loss of dopaminergic neurons in the midbrain substantia nigra. Thus, the most important for using ES cells in PD therapy is to direct their differentiation into dopaminergic phenotype to replace the degenerated cells. In this review, we summarize the neural differentiation directing protocol, transplantation results, and behavioral recovery of ES cells derived dopaminergic neurons in the therapeutic studies in PD animal models.

Key Words:  embryonic stem cells , Parkinson's disease

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PII: S2211-4254(11)60004-6

doi:10.1016/S2211-4254(11)60004-6

Genomic Medicine, Biomarkers, and Health Sciences
Volume 3, Issue 1 , Pages 17-26, March 2011

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